CHP Home GenChem     Analytical     Instrumentation     Index   



Making measurements with any analytical method or instrument requires calibration to ensure the accuracy of the measurement. There are two common calibration procedures: using a working curve, and the standard-addition method. Both of these methods require one or more standards of known composition to calibrate the measurement.

Instrumental methods are usually calibrated with standards that are prepared (or purchased) using a non-instrumental analysis. There are two direct analytical methods: gravimetry and coulometry. Titration is similar but requires preparation of a primary standard.

The chief advantage of the working curve method is that it is rapid in that a single set of standards can be used for the measurement of multiple samples. The standard-addition method requires multiple measurements for each sample, but can reduce inaccuracies due to interferences and matrix effects.

Related topics:

 Top of Page   
 Copyright © 2000 by Brian M. Tissue, all rights reserved.